Isoprenaline Hydrochloride cirbadeynta xididka

Tilmaamaha:

1. Daawaynta shoog wadnaha ah ama septic;
2. Maareynta xannibaadda atrioventricular (AV) oo dhammaystiran iyo xiritaanka wadnaha.

Falka Farmasiga:
Isoprenaline waa agonist receptor β-adrenergic aan la dooran oo leh firfircooni xoog leh labadaba β₁ iyo β₂ reseptors.

• At β₁ reseptors (inta badan wadnaha), waxay ku shaqeysaa inotropic togan oo xoog leh (kordhinta qandho), dromotropic (kordhinta korriinka), iyo chromotropic (garaaca garaaca wadnaha oo kordhay) - aad uga muuqda kuwa epinephrine.
• At β₂ reseptors (ugu horreyntii muruqa siman ee xididdada muruqa lafaha, beerka, iyo halbowlayaasha wadnaha), waxay keentaa vasodilation, taasoo keenta hoos u dhac ku yimaada celceliska cadaadiska halbowlaha (MAP).

Sababo la xiriira kicinta wadnaha ee isku xiran iyo vasodilation durugsan, isoprenaline caadi ahaan waxay sababtaa:

• Kor u kaca cadaadiska dhiigga ee systolic (laga bilaabo wax soo saarka wadnaha oo la xoojiyay);
• Hoos u dhaca cadaadiska dhiigga ee diastolic (laga bilaabo iska caabbinta durugsan oo yaraatay);
• Cadaadiska garaaca wadnaha oo ballaaran.