Daawooyinka Durida Epinephrine Hydrochloride

Cirbadaha Epinephrine Hydrochloride

Magaca Alaabta: Durida Epinephrine Hydrochloride. Cirbadaha Epipephrine Hydrochloride waa mid ka mid ah duritaanka mugga yar, cirbadeynta dhalada.

Kala saarista: Daawooyinka Galbeedka. Dawooyinka Dawada.

Tilmaamaha:
Epinephrine hydrochloride waxaa ugu horayn loo isticmaalaa goobaha caafimaadka degdega ah, gaar ahaan xaaladaha nafta halis gelinaya. Tilmaamaha muhiimka ah waxaa ka mid ah:

• Neefsasho daran oo ay keento bronchospasm (tusaale, neefta daran ama anaphylaxis)
• Dib-u-noqosho degdeg ah oo shoogga anaphylactic ay keentay daroogooyinka, xasaasiyadaha, ama kiciyeyaasha kale
• Kordhinta muddada ficilka suuxinta maxalliga ah marka loo isticmaalo wax lagu daro suuxinta galitaanka
• Wakiilka dib u soo kicinta safka hore ee dib u soo kicinta wadnaha sambabada (CPR) ee wadnaha oo istaagay sababo kala duwan

Falka Farmasiga:
Epinephrine hydrochloride waa wakiilka sympathomimetic awood leh oo sidoo kale u shaqeeya sida hoormoon endogenous iyo neurotransmitter. Waxay si aan ikhtiyaari ahayn u hawlgelisaa labadaba α- iyo β-adrenergic reseptors, taasoo soo saarta saameyno nafsiyeed oo badan oo muhiim ah:

• α₁-receptor activation : Waxay keentaa vasoconstriction, taasoo keentay in ay kordho iska caabbinta xididdada dhiigga iyo cadaadiska dhiigga, iyo yaraynaysaa bararka xuubka (gaar ahaan marinnada hawada).
• β₁-receptor activation : Kicin wadnaha, taasoo keentay in kor u garaaca wadnaha (chronotropy), kor u qaadis myocardial contractility (inotropy), iyo hagaajinta wax soo saarka wadnaha.
• β₂-receptor activation : Waxay keentaa nasinta murqaha siman ee boronkiitada, si degdeg ah u yareeya xiiqda iyo bronchospasm; Waxa kale oo ay keentaa vasodilation ee xididdada murqaha lafaha.

Dhaqdhaqaaqa soo-dhoweynta ee wejiyada badan leh ayaa awood u siinaya epinephrine in uu isku mar wax ka qabto saddexda qaybood ee pathophysiological ee asaasiga ah ee shoogga anaphylactic: hypotension (iyada oo loo marayo α₁-dhexdhexaadin vasoconstriction), xannibaadda marin-haweedka (iyada oo loo marayo β₂-dhexdhexaadinta bronchodilation iyo α₁-dhexdhexaadin hoos u dhigista bararka hawada hawada sare), iyo burburka wareegga wareegga (via cardiac media). Guryahani waxay ka dhigaan dawada la doortay ee anaphylaxis iyo xiritaanka wadnaha.