Magaca Alaabta: Durida Pentoxifylline
Tilmaamaha:
- Xanuunada wareegga dhiigga ee maskaxda, sida weerarrada ischaemic ee ku-meel-gaadhka ah (TIAs), daba-galka istaroogga, iyo cillad maskaxeed oo uu keeno ischemia maskaxda;
- Xanuunada wareegga wareegga, oo ay ku jiraan thromboangiitis obliterans, xannibaadda halbowlaha caloosha, claudication kala go'a, iyo xanuunka nasashada;
- Qalalaasaha wareegga dhiigga ee gudaha dhegta, sida lumista maqalka dareenka degdega ah, tinnitus da'da la xiriirta, iyo presbycusis (maqal la'aanta da'da);
- Xanuunada wareegga dhiigga ee indhaha, sida xannibaadda xididdada isha ee sonkorowga.
Falka Farmasiga:
Pentoxifylline waa alkaloid ka soo jeeda theobromine-asal ahaan laga soo saaray digirta kookaha-oo leh koox hexanone ah oo lagu soo bandhigay qaab dhismeedkeeda. Waa derivative methylxanthine oo la isticmaalay ilaa 1960-meeyadii si loogu daweeyo xanuunnada wareegga wareegga dhiigga oo markii dambe loo qaatay sidii wakiilka vasodilatory ee cudurrada xididdada dhiigga ee kala duwan.
Hababka ay ku shaqeyso waxaa ka mid ah:
- Kordhinta deformability erythrocyte, taas oo hagaajinaysa socodka microcirculatory;
- Yaraynta adhesion neutrophils iyo isku-darka;
- Hoos u dhigista viscosity dhiiga iyo hagaajinta sifooyinka dhiigbaxa;
- Kicinta unugyada xididada xididada xididada si ay u sii daayaan prostacyclins (PGI₂ iyo PGI₃) iyada oo la xakameynayo isku-dhafka endothelin, taasoo keentay vasodilation;
- Joojinta isku-darka platelet iyo soosaarka fibrinogen, sidaas awgeed ka hortagga samaynta thrombus;
- Xakamaynta NF-κB-dhexdhexaadinta qoraalka mRNA, taasoo horseedaysa hoos u dhaca wax soo saarka buro necrosis factor-alpha (TNF-α).